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Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ

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Spiking/recovery tests were performed to determine the optimal dilution factor, particularly for the kits lacking manufacturer-provided serum dilution guidelines [human pro-BDNF DuoSet ELISA kit (#DY3175, R&D Systems) and high-sensitivity pro-BDNF human ELISA kit (#SK00752-09, Aviscera Bioscience)]

Methods: We have identified 138 atrial fibrillation (AF) patients with ischemic stroke from January 2018 to January 2021 who were not suitable to take DOAC and discussed at the institutional brain-heart case conference prior to LAAO

Yasuhara T, Shingo T et al (2004) Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinsons disease